Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.77 |
| ▸ | DRD3 | P35462 | 19/20 | 0.77 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852727 | 1.00 | DRD2 (0.77) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7976656 | 0.97 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7976661 | 0.97 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7850257 | 0.88 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7853543 | 0.88 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL5899241 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL5899238 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL5899240 | 0.87 | DRD2 (1.00) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7851315 | 0.86 | DRD3 (0.70) | DRD2DRD3HTR1DHTR1BCCR2 | |
| SCHEMBL7852346 | 0.86 | DRD3 (0.70) | DRD2DRD3HTR1DHTR1BCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922035-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | claimed |
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | claimed |
| EP-0922035-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | disclosed |