Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 5/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7852254 | 0.87 | HDAC3 (0.54) | ADRA1DADRA1AADRA1BHDAC3HDAC4 | |
| SCHEMBL7845729 | 0.81 | KMT2A (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL32682699 | 0.76 | HDAC8 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL21617956 | 0.74 | CHRNA7 (0.50) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7849142 | 0.74 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BHDAC3HDAC4 | |
| SCHEMBL8565854 | 0.74 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BKCNH2 | |
| SCHEMBL8566160 | 0.74 | ADRA1D (0.67) | ADRA1DADRA1AADRA1BKCNH2 | |
| SCHEMBL7852840 | 0.74 | KMT2A (0.54) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL7841681 | 0.72 | ADRA1D (0.85) | ADRA1DADRA1AADRA1BKCNH2 | |
| SCHEMBL8564005 | 0.71 | ADRA1D (0.66) | ADRA1DADRA1AADRA1BHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831824-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2001-05-02 | — | — | EP | disclosed |
| EP-0831824-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996039140-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |