SCHEMBL7843943

SCHEMBL7843943

CCc1ccc2c(=O)c3ccc(CC)cc3ccc2c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.54
CYP2A6 P11509 1/20 0.54
AKR1B1 P15121 2/20 0.50
ELANE P08246 2/20 0.45
AKR1C3 P42330 1/20 0.43
AKR1C2 P52895 1/20 0.43
DAO P14920 1/20 0.43
NPC1 O15118 2/20 0.42
ALDH1A1 P00352 2/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
LMNA P02545 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TYMS P04818 1/20 0.41
KIF11 P52732 1/20 0.40
TRPA1 O75762 1/20 0.40
KDM4E B2RXH2 1/20 0.39
GABRA1 P14867 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9765522 0.91 AKR1B1 (0.64) CYP1A2CYP2A6AKR1B1ELANENPC1
SCHEMBL9765513 0.80 CYP1A2 (0.57) CYP1A2CYP2A6AKR1B1NPC1ALDH1A1
SCHEMBL29407167 0.78 CYP2A6 (0.80) CYP1A2CYP2A6AKR1C3AKR1C2DAO
SCHEMBL347592 0.78 CYP2A6 (0.80) CYP1A2CYP2A6AKR1C3AKR1C2DAO
SCHEMBL8653130 0.78 CYP1A2 (0.48) CYP1A2CYP2A6ELANEAKR1C3AKR1C2
SCHEMBL598696 0.77 CYP1A2 (0.69) CYP1A2CYP2A6AKR1B1ALDH1A1MAPT
SCHEMBL18725322 0.76 TYMS (0.43) CYP1A2CYP2A6ELANEDAONPC1
SCHEMBL4123235 0.76 CYP1A2 (0.47) CYP1A2CYP2A6ELANEAKR1C3AKR1C2
SCHEMBL3949360 0.76 CYP1A2 (0.47) CYP1A2CYP2A6ELANEAKR1C3AKR1C2
SCHEMBL9765541 0.76 AKR1B1 (0.60) CYP1A2CYP2A6AKR1B1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0984963-B1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2001-04-11 EP disclosed
US-6162808-A Compounds ASTRAZENECA U.K. LIMITED (GB) 2000-12-19 US disclosed