Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.60 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9765513 | 0.91 | CYP1A2 (0.57) | AKR1B1CYP1A2CYP2A6KIF11ALDH1A1 | |
| SCHEMBL7843943 | 0.91 | CYP1A2 (0.54) | AKR1B1CYP1A2CYP2A6KIF11ALDH1A1 | |
| SCHEMBL598696 | 0.89 | CYP1A2 (0.69) | AKR1B1CYP1A2CYP2A6KIF11ALDH1A1 | |
| SCHEMBL7773085 | 0.87 | CYP1A2 (0.67) | AKR1B1CYP1A2CYP2A6KIF11ALDH1A1 | |
| SCHEMBL9765541 | 0.86 | AKR1B1 (0.60) | AKR1B1CYP1A2CYP2A6ALDH1A1MAPT | |
| SCHEMBL9765531 | 0.83 | AKR1B1 (0.57) | AKR1B1CYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL11711988 | 0.82 | AKR1B1 (0.64) | AKR1B1CYP1A2CYP2A6ALDH1A1MAPT | |
| SCHEMBL11712119 | 0.81 | AKR1B1 (0.62) | AKR1B1CYP1A2CYP2A6ALDH1A1MAPT | |
| SCHEMBL11732367 | 0.80 | AKR1B1 (0.54) | AKR1B1CYP1A2CYP2A6ALDH1A1MAPT | |
| SCHEMBL11704584 | 0.79 | AKR1B1 (0.65) | AKR1B1CYP1A2ALDH1A1MAPTMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0272621-B1 | Method for the production of 5H-dibenzo[a,d]cyclohepten-5-ones | BASF Aktiengesellschaft (DE) | 1991-11-27 | — | — | EP | disclosed |
| US-4845302-A | Preparation of 5H-dibenzo[a,d]cyclohepten-5-ones | BASF AKTIENGSELLSCHAFT (DE) | 1989-07-04 | — | — | US | disclosed |
| EP-0272621-A2 | Method for the production of 5H-dibenzo[a,d]cyclohepten-5-ones | BASF Aktiengesellschaft (DE) | 1988-06-29 | — | — | EP | disclosed |
| US-4011243-A | Intermediate in the oxidative process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids | SYNTEX (U.S.A.) INC. (US) | 1977-03-08 | — | — | US | disclosed |
| US-3979430-A | Solvolytic process for the preparation of 2-(5H-dibenzo[a,d]cyclohepten-5-on-2-yl)acetic, propionic and butyric acids | SYNTEX (U.S.A.) INC. (US) | 1976-09-07 | — | — | US | disclosed |