SCHEMBL7844082

SCHEMBL7844082

CSc1ccc(C=C(C(=O)O)c2ccsc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 5/20 0.67
AKR1C1 Q04828 5/20 0.67
AKR1C2 P52895 4/20 0.67
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
CTDSP1 Q9GZU7 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
POLB P06746 2/20 0.44
ALDH1A1 P00352 1/20 0.43
RXFP1 Q9HBX9 1/20 0.43
LCK P06239 1/20 0.42
FYN P06241 1/20 0.42
DAO P14920 1/20 0.42
PTGS2 P35354 2/20 0.40
MAPT P10636 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
KDM4E B2RXH2 1/20 0.39
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844079 1.00 AKR1C3 (0.67) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL7383322 0.82 AKR1C1 (0.65) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL5457557 0.82 AKR1C1 (0.65) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL11557849 0.81 ALDH1A1 (0.59) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL11557846 0.81 ALDH1A1 (0.59) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL7842239 0.80 AKR1C3 (1.00) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL7842236 0.80 AKR1C3 (1.00) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL7046304 0.78 MEN1 (0.44) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL7046303 0.78 MEN1 (0.44) AKR1C3AKR1C1AKR1C2MEN1KMT2A
SCHEMBL3040559 0.77 AKR1C3 (0.75) AKR1C3AKR1C1AKR1C2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1125932-A2 Substituted thiazoles for the treatment of inflammation G.D. SEARLE & CO. (US) 2001-08-22 EP disclosed
EP-0772606-A1 SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-05-14 EP disclosed
WO-1996003392-A1 SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-02-08 WO disclosed