Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.64 |
| ▸ | HTR2C | P28335 | 5/20 | 0.64 |
| ▸ | HTR2B | P41595 | 5/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL905820 | 0.85 | HTR2A (0.65) | HTR2AHTR2CHTR2BHRH3NR1I2 | |
| SCHEMBL7840357 | 0.79 | ALDH1A1 (0.42) | HTR2AHTR2CHTR2BDRD2CYP3A4 | |
| SCHEMBL905818 | 0.78 | HTR2A (1.00) | HTR2AHTR2CHTR2BHRH3NR1I2 | |
| Hydrochloric Acid SCHEMBL7845930 | 0.77 | HTR2A (0.57) | HTR2AHTR2CHTR2BHRH3CHRM2 | |
| SCHEMBL7674589 | 0.76 | HTR2A (0.58) | HTR2AHTR2CHTR2BCHRM2CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL905765 | 0.75 | HTR2A (0.53) | HTR2AHTR2CHTR2BCYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL7840936 | 0.74 | DRD1 (0.47) | HRH3DRD2DRD1DRD3 | |
| SCHEMBL7833297 | 0.72 | HTR2A (0.42) | HTR2AHTR2CHTR2BHRH3HTR1A | |
| Ammonia Solution, Strong SCHEMBL905761 | 0.71 | HTR2A (0.62) | HTR2AHTR2CHTR2BDRD2DRD1 | |
| SCHEMBL6216648 | 0.71 | ALDH1A1 (0.72) | HTR2ACHRM2CHRM1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | claimed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | claimed |
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |