Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.70 |
| ▸ | DRD3 | P35462 | 19/20 | 0.70 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843879 | 1.00 | DRD2 (0.70) | DRD2DRD3DRD1DRD4HDAC3 | |
| SCHEMBL7854682 | 0.88 | DRD2 (0.78) | DRD2DRD3DRD1DRD4HDAC3 | |
| SCHEMBL7850964 | 0.88 | DRD2 (0.78) | DRD2DRD3DRD1DRD4HDAC3 | |
| SCHEMBL7852348 | 0.88 | DRD2 (0.72) | DRD2DRD3HDAC3HDAC4HDAC1 | |
| SCHEMBL7852478 | 0.88 | DRD2 (0.72) | DRD2DRD3HDAC3HDAC4HDAC1 | |
| SCHEMBL7852519 | 0.86 | DRD2 (0.72) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7850791 | 0.86 | DRD2 (0.82) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7850789 | 0.86 | DRD2 (0.82) | DRD2DRD3HTR1DHTR1B | |
| SCHEMBL7850177 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7850184 | 0.85 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922035-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | claimed |
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | claimed |
| EP-0922035-B1 | TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-6143762-A | DRUGS AS DOPAMINE ANTAGONIST PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, PLC (GB) | 2000-11-07 | — | — | US | disclosed |