Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846159 | 0.93 | MAOB (0.47) | PTGS2MAOBMAPTLMNAL3MBTL1 | |
| SCHEMBL7843454 | 0.93 | MAOB (0.50) | PTGS2MAOBPTGS1ROCK2 | |
| SCHEMBL7832865 | 0.93 | PTGS2 (0.44) | PTGS2MAOBPTGS1ALOX5MAPT | |
| SCHEMBL7846336 | 0.92 | PTGS2 (0.48) | PTGS2MAOBPTGS1MAPTLMNA | |
| SCHEMBL7843859 | 0.92 | TP53 (0.43) | PTGS2MAOBPTGS1MAPTCNR1 | |
| SCHEMBL7832889 | 0.90 | MAPT (0.47) | PTGS2MAOBMAPTLMNAALDH1A1 | |
| SCHEMBL7840239 | 0.89 | TP53 (0.48) | PTGS2MAOBPTGS1MAPTLMNA | |
| SCHEMBL7844960 | 0.89 | PTGS2 (0.45) | PTGS2MAOBPTGS1MAPTLMNA | |
| SCHEMBL7843267 | 0.88 | MAOB (0.48) | PTGS2MAOBPTGS1MAPTCNR1 | |
| SCHEMBL7844443 | 0.88 | MAOB (0.42) | PTGS2MAOBPTGS1LMNAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |