Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841302 | 0.97 | PTGS2 (0.51) | PTGS2PTGS1ALOX5PPARDNPC1 | |
| SCHEMBL7842156 | 0.93 | PTGS2 (0.48) | PTGS2PTGS1ALOX5PPARDNPC1 | |
| SCHEMBL7833513 | 0.92 | PTGS2 (0.53) | PTGS2PTGS1ALOX5PPARDNPC1 | |
| SCHEMBL7833526 | 0.92 | PTGS2 (0.48) | PTGS2PTGS1GRM5ALOX5PPARD | |
| SCHEMBL7845661 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1ALOX5PPARDNPC1 | |
| SCHEMBL7843072 | 0.92 | PTGS2 (0.52) | PTGS2PTGS1ALOX5PPARD | |
| SCHEMBL7840138 | 0.92 | PTGS2 (0.53) | PTGS2PTGS1GRM5ALOX5PPARD | |
| SCHEMBL7843634 | 0.90 | PTGS2 (0.55) | PTGS2PTGS1ALOX5PPARDRAB9A | |
| SCHEMBL7839942 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1GRM5ALOX5PPARD | |
| SCHEMBL6246548 | 0.89 | PTGS2 (0.65) | PTGS2PTGS1ALOX5PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |