Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841914 | 0.92 | PTGS2 (0.55) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7844544 | 0.88 | PTGS2 (0.45) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7846633 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7832883 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7841008 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7846434 | 0.82 | PTGS2 (0.65) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7843825 | 0.82 | PTGS2 (0.55) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7843832 | 0.81 | PTGS2 (0.59) | PTGS2PTGS1HSD11B1L3MBTL1ALDH1A1 | |
| SCHEMBL7842150 | 0.81 | PTGS2 (0.51) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL7846621 | 0.81 | PTGS2 (0.60) | PTGS2PTGS1L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |