Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ROS1 | P08922 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 7/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4393755 | 0.79 | GSK3B (0.50) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4393758 | 0.79 | ROS1 (0.53) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5093917 | 0.78 | GSK3B (0.47) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4398386 | 0.78 | GSK3B (0.41) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL7024110 | 0.77 | GSK3B (0.44) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL4972846 | 0.77 | GSK3B (0.52) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL7022602 | 0.76 | GSK3B (0.63) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5089268 | 0.76 | GSK3B (0.48) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL27538055 | 0.76 | GSK3B (0.57) | GSK3BCCNB2CDK1CCNB1GSK3A | |
| SCHEMBL5099514 | 0.76 | GSK3B (0.46) | GSK3BCCNB2CDK1CCNB1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |