Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842150 | 0.90 | PTGS2 (0.51) | PTGS2PTGS1ALOX5KDM4EALDH1A1 | |
| SCHEMBL7832430 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1CYP1A1CYP1B1KDM4E | |
| SCHEMBL7843825 | 0.89 | PTGS2 (0.55) | PTGS2PTGS1CYP1A1CYP1B1KDM4E | |
| SCHEMBL7846290 | 0.88 | PTGS2 (0.49) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7842651 | 0.87 | PTGS2 (0.59) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7844544 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7846621 | 0.83 | PTGS2 (0.60) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7839678 | 0.82 | PTGS2 (0.65) | PTGS2PTGS1 | |
| SCHEMBL7846633 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7843877 | 0.81 | PTGS2 (0.61) | PTGS2PTGS1CYP1A1CYP1B1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |