Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 13/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844855 | 1.00 | FBP1 (0.55) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL4230227 | 0.86 | EGFR (0.62) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL4222324 | 0.86 | EGFR (0.62) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL4231429 | 0.85 | EGFR (0.68) | EGFRERBB2KDRHDAC3HDAC1 | |
| SCHEMBL4231150 | 0.85 | EGFR (0.68) | EGFRERBB2KDRHDAC3HDAC1 | |
| SCHEMBL2998293 | 0.84 | EGFR (0.61) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL2995000 | 0.82 | FBP1 (0.67) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL2996285 | 0.82 | EGFR (0.71) | EGFRERBB2ERBB4KDRGAK | |
| SCHEMBL7854521 | 0.80 | EGFR (0.59) | FBP1EGFRERBB2ERBB4KDR | |
| SCHEMBL2991327 | 0.77 | EGFR (0.53) | EGFRERBB2KDRSRCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163227-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055141-A1 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |