Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | GALR2 | O43603 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853525 | 0.90 | MCHR1 (0.47) | EGFRERBB2ERBB4AURKAAURKB | |
| SCHEMBL7855449 | 0.84 | EGFR (0.46) | EGFRERBB2AURKAAURKBGALR2 | |
| SCHEMBL7853506 | 0.84 | EGFR (0.46) | EGFRERBB2ERBB4JAK3KDR | |
| SCHEMBL7853244 | 0.84 | HPGD (0.48) | EGFRERBB2ERBB4AURKAAURKB | |
| SCHEMBL7855000 | 0.83 | EGFR (0.43) | EGFRERBB2GALR2PDGFRB | |
| SCHEMBL7851830 | 0.83 | GALR2 (0.42) | EGFRERBB2ERBB4AURKAAURKB | |
| SCHEMBL7852279 | 0.82 | EGFR (0.48) | EGFRERBB2ERBB4GALR2PDGFRB | |
| SCHEMBL7853143 | 0.81 | MCHR1 (0.43) | EGFRERBB2ERBB4MCHR1 | |
| SCHEMBL7851258 | 0.81 | EGFR (0.44) | EGFRERBB2GALR2PDGFRB | |
| SCHEMBL7853619 | 0.81 | GALR2 (0.43) | EGFRERBB2ERBB4JAK3GALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |