Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 13/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853143 | 0.91 | MCHR1 (0.43) | MCHR1EGFRERBB3ERBB2ERBB4 | |
| SCHEMBL7853244 | 0.90 | HPGD (0.48) | MCHR1EGFRERBB3ERBB2ERBB4 | |
| SCHEMBL7845264 | 0.90 | EGFR (0.47) | MCHR1EGFRERBB2ERBB4JAK3 | |
| SCHEMBL7852723 | 0.83 | EGFR (0.47) | EGFRERBB3ERBB2ERBB4HPGD | |
| SCHEMBL7852078 | 0.82 | MALT1 (0.45) | EGFRERBB3ERBB2KMO | |
| SCHEMBL7852813 | 0.82 | EGFR (0.42) | MCHR1EGFRERBB3ERBB2ERBB4 | |
| SCHEMBL7856240 | 0.82 | MALT1 (0.43) | MCHR1EGFRERBB3ERBB2 | |
| SCHEMBL7855449 | 0.81 | EGFR (0.46) | MCHR1EGFRERBB2AURKAAURKB | |
| SCHEMBL8630143 | 0.81 | EGFR (0.46) | EGFRERBB3ERBB2ERBB4JAK3 | |
| SCHEMBL7853953 | 0.79 | GALR2 (0.40) | EGFRERBB3ERBB2ERBB4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163242-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | Boehringer Ingelheim Pharma KG (DE) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000055162-A2 | BICYCLIC HETEROCYCLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESSES FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-21 | — | — | WO | disclosed |