SCHEMBL7845320

SCHEMBL7845320

CC(=O)Nc1ccc2c(c1)OC1(CCNCC1)CC2=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 9/20 0.58
HDAC4 P56524 9/20 0.58
HDAC1 Q13547 9/20 0.58
HDAC7 Q8WUI4 9/20 0.58
HDAC2 Q92769 9/20 0.58
HDAC10 Q969S8 9/20 0.58
HDAC11 Q96DB2 9/20 0.58
HDAC8 Q9BY41 9/20 0.58
HDAC6 Q9UBN7 9/20 0.58
HDAC9 Q9UKV0 9/20 0.58
HDAC5 Q9UQL6 9/20 0.58
CYP1A2 P05177 1/20 0.43
CYP2C19 P33261 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
GABRD O14764 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRB1 P18505 1/20 0.42
GABRA5 P31644 1/20 0.42
GABRA3 P34903 1/20 0.42
GABRA2 P47869 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1811484 0.91 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL11108781 0.88 KDM4E (0.52) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL13339692 0.84 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL3491586 0.83 HDAC3 (0.57) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7849142 0.81 ADRA1D (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL744065 0.79 HDAC3 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL4278683 0.79 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18148314 0.79 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL18148497 0.78 HDAC3 (0.60) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL18148539 0.77 HDAC3 (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831824-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2001-05-02 EP disclosed
EP-0831824-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-04-01 EP disclosed
WO-1996039140-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-12-12 WO disclosed