SCHEMBL7845517

SCHEMBL7845517

CCC(C)CCCOc1nsnc1Cl

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 8/20 0.35
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
HTR1A P08908 1/20 0.33
CHRM5 P08912 1/20 0.33
ADRA2A P08913 1/20 0.33
CHRM3 P20309 1/20 0.33
MAOA P21397 1/20 0.33
DRD1 P21728 1/20 0.33
ACHE P22303 1/20 0.33
SLC6A2 P23975 1/20 0.33
PDE4A P27815 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33
DRD3 P35462 1/20 0.33
HTR2B P41595 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KCNH2 Q12809 1/20 0.33
CACNA1C Q13936 1/20 0.33
SCN5A Q14524 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8445786 0.85 CHRM1 (0.35) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL7851759 0.80 CHRM1 (0.51) CHRM1CHRM2CHRM4HTR1ACHRM5
SCHEMBL8442739 0.78 CHRM1 (0.49) CHRM1CHRM2CHRM4HTR1ACHRM5
SCHEMBL7847876 0.77 CHRM1 (0.50) CHRM1CHRM2CHRM4HTR1ACHRM5
SCHEMBL7846959 0.77 CHRM1 (0.33) CHRM1
SCHEMBL6912310 0.71 CHRM1 (0.75) CHRM1CHRM2CHRM4HTR1ACHRM5
SCHEMBL8789693 0.70 CHRM1 (0.33) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL9038054 0.67
SCHEMBL8788276 0.66
SCHEMBL8150986 0.64 PDE3B (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098883-A4 PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS LILLY CO ELI (US) 2001-11-14 EP disclosed
EP-1098883-A1 PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 2001-05-16 EP disclosed
WO-1998054151-A1 PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS ELI LILLY AND COMPANY (US) 1998-12-03 WO disclosed