Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701620 | 1.00 | ALDH1A1 (0.44) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL13244922 | 1.00 | ALDH1A1 (0.44) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Hydrochloric Acid SCHEMBL4701828 | 0.98 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2CYP2C19 | |
| Hydrochloric Acid SCHEMBL4700390 | 0.98 | ALDH1A1 (0.43) | ALDH1A1PREPSMN1; SMN2CYP2C19 | |
| SCHEMBL13244810 | 0.91 | ALDH1A1 (0.42) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Bromide SCHEMBL3119408 | 0.90 | ALDH1A1 (0.41) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Bromide SCHEMBL3119410 | 0.90 | ALDH1A1 (0.41) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Trifluoroacetic Acid SCHEMBL4700417 | 0.89 | PREP (0.40) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Trifluoroacetic Acid SCHEMBL4700336 | 0.89 | PREP (0.40) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 | |
| Bromide SCHEMBL3119404 | 0.88 | PREP (0.40) | ALDH1A1PREPSMN1; SMN2CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535645-B1 | Carbamate derivatives of 4-amino-3-isoxazolidinones and 3-amino-1-hydroxypyrrolidin-2-ones, a process for their preparation and their use as medicaments | AVENTIS PHARMA INC (US) | 2001-05-09 | — | — | EP | disclosed |
| EP-1069125-A2 | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs, a process for their preparation and their use as medicaments | AVENTIS PHARMACEUTICALS INC. (US) | 2001-01-17 | — | — | EP | disclosed |
| US-5234941-A | Cognition activators; Alzheimer's disease; cholinergic agents; acetylchloinesterase inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-10 | — | — | US | disclosed |
| US-5231093-A | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0535645-A2 | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-04-07 | — | — | EP | disclosed |
| US-5153193-A | Nootropic, cholinergic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-06 | — | — | US | disclosed |