Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29986282 | 0.85 | KDM4E (0.48) | KMT2AMEN1SMN1; SMN2CYP19A1MAPT | |
| SCHEMBL15696821 | 0.85 | KDM4E (0.48) | KMT2AMEN1SMN1; SMN2CYP19A1MAPT | |
| SCHEMBL25461647 | 0.80 | CYP3A4 (0.42) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL25461646 | 0.80 | ALDH1A1 (0.43) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL15695186 | 0.79 | CLK4 (0.44) | KMT2AMEN1SMN1; SMN2CYP19A1MAPT | |
| SCHEMBL25461649 | 0.79 | CYP1A2 (0.44) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL25461256 | 0.79 | KDM4E (0.45) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL25461655 | 0.78 | MEN1 (0.40) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL25461652 | 0.78 | NCOA1 (0.40) | KMT2AMEN1SMN1; SMN2MAPTNPC1 | |
| SCHEMBL19083008 | 0.78 | MEN1 (0.41) | KMT2AMEN1SMN1; SMN2MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1136493-A1 | 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives | SANOFI-SYNTHELABO (FR) | 2001-09-26 | — | — | EP | disclosed |