Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | GRK2 | P25098 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.41 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.35 |
| ▸ | GRK3 | P35626 | 1/20 | 0.35 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5257940 | 0.85 | MAPK14 (0.45) | ROCK2GRK2MAPK1MAPK3MAPK14 | |
| SCHEMBL5256306 | 0.81 | MAPK14 (0.50) | ROCK2GRK2MAPK14 | |
| SCHEMBL7856762 | 0.73 | IDO1 (0.42) | ROCK2GRK2HSP90AA1MAPK14CYP1A2 | |
| SCHEMBL5454667 | 0.70 | LRRK2 (0.50) | MAPK1LRRK2HSP90AA1MAPK14MEN1 | |
| SCHEMBL5258122 | 0.67 | MAPK14 (0.48) | ROCK2GRK2MAPK14CYP1A2 | |
| SCHEMBL7844639 | 0.66 | MAPK11 (0.44) | MAPK14CDK2CCNE2CCNE1 | |
| SCHEMBL5452469 | 0.65 | MAPK14 (0.47) | ROCK2GRK2MAPK14 | |
| SCHEMBL14411921 | 0.64 | MAPK14 (0.48) | LRRK2MAPK14 | |
| SCHEMBL5332014 | 0.63 | MAPK14 (0.59) | ROCK2GRK2MAPK1MAPK3MAPK14 | |
| SCHEMBL14411809 | 0.63 | MAPK14 (0.46) | MAPK14CDK2CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144403-A1 | SUBSTITUED PYRAZOLES AS P38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000031063-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-06-02 | — | — | WO | disclosed |