Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847494 | 0.91 | CCNT1 (0.40) | CCNT1CDK7CDK9CCNHKDM4E | |
| SCHEMBL3421020 | 0.80 | BRD4 (0.48) | CCNT1CDK7CDK9CCNHHSD17B10 | |
| SCHEMBL7003833 | 0.74 | MEN1 (0.45) | CCNT1CDK7CDK9CCNHHSD17B10 | |
| SCHEMBL7003831 | 0.74 | MEN1 (0.45) | CCNT1CDK7CDK9CCNHHSD17B10 | |
| SCHEMBL6998414 | 0.73 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHKDM4E | |
| SCHEMBL6998422 | 0.73 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHKDM4E | |
| SCHEMBL6998419 | 0.73 | CDK7 (0.39) | CCNT1CDK7CDK9CCNHKDM4E | |
| SCHEMBL7003771 | 0.73 | CCNT1 (0.42) | CCNT1CDK7CDK9CCNH | |
| SCHEMBL7003766 | 0.73 | CCNT1 (0.42) | CCNT1CDK7CDK9CCNH | |
| SCHEMBL6998608 | 0.72 | ABCB1 (0.39) | ABCB1KDM4EMAPK10NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714898-B1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| EP-0714898-A1 | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-05 | — | — | EP | disclosed |