Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842479 | 1.00 | PTGS2 (0.62) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7833741 | 0.95 | PTGS2 (0.61) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7846092 | 0.95 | PTGS2 (0.61) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7842695 | 0.91 | PTGS2 (0.55) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7843314 | 0.91 | PTGS2 (0.55) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7847022 | 0.91 | PTGS2 (0.60) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7843109 | 0.91 | PTGS2 (0.60) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7844500 | 0.90 | PTGS2 (0.56) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7842268 | 0.90 | PTGS2 (0.65) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E | |
| SCHEMBL7841748 | 0.90 | PTGS2 (0.56) | PTGS2SMN1; SMN2KMT2ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |