Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.85 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA3 | P07451 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7845239 | 0.94 | PTGS2 (0.83) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7843002 | 0.94 | PTGS2 (0.83) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7844120 | 0.93 | PTGS2 (0.81) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7845235 | 0.93 | PTGS2 (0.81) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7841042 | 0.93 | PTGS2 (0.80) | PTGS2PTGS1KDM4EALDH1A1RXFP1 | |
| SCHEMBL7833820 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7844945 | 0.92 | PTGS2 (0.80) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7841574 | 0.92 | PTGS2 (0.80) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7833933 | 0.90 | PTGS2 (0.77) | PTGS2PTGS1CA1CA2CA12 | |
| SCHEMBL7843865 | 0.90 | PTGS2 (0.77) | PTGS2PTGS1CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |