Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | RAC1 | P63000 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16431777 | 0.85 | MAPT (0.44) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL149852 | 0.80 | RAC1 (0.56) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL16432376 | 0.75 | EGFR (0.40) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL13518921 | 0.74 | KDM4E (0.56) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7822956 | 0.73 | KDM4E (0.83) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29118699 | 0.73 | WHR1 (0.57) | KDM4EMAPTRAC1GAAALDH1A1 | |
| SCHEMBL3321880 | 0.73 | KDM4E (0.80) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3320127 | 0.73 | KDM4E (0.75) | KDM4EMEN1KMT2ANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3318463 | 0.72 | KDM4E (0.78) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3324961 | 0.72 | KDM4E (1.00) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129076-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000029380-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES AS LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-05-25 | — | — | WO | disclosed |
| US-5889018-A | ADMINISTERING TO THE PATIENT SUFFERING FROM ANXIETY A 1-STYRYLISOQUINOLINE COMPOUND AS AN ANXIOLYTIC AGENT | EGIS GYOGYSZERGYAR RT. (HU) | 1999-03-30 | — | — | US | disclosed |
| EP-0680953-A1 | 1-[Styryl]- and 1-[2'-(heteroaryl)-ethenyl]-isoquinoline derivatives, a process for preparing them as well as medicaments containing them and the use of them | EGIS GYOGYSZERGYAR RT. (HU) | 1995-11-08 | — | — | EP | disclosed |