Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 2/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3549192 | 0.83 | NPC1 (0.41) | NPC1RAB9AKDM4EHPGDBCL2 | |
| SCHEMBL4487068 | 0.80 | KDM4E (0.49) | NPC1RAB9AKDM4EHPGDBCL2 | |
| SCHEMBL26148249 | 0.76 | CA12 (0.40) | NPC1RAB9AKDM4EHPGDBRD9 | |
| SCHEMBL4481762 | 0.75 | NPC1 (0.41) | NPC1RAB9AKDM4EHPGDBCL2 | |
| SCHEMBL3275997 | 0.75 | ACVRL1 (0.48) | NPC1RAB9AKDM4EHPGD | |
| SCHEMBL4487659 | 0.75 | AOC3 (0.42) | NPC1RAB9AKDM4EHPGDBCL2 | |
| SCHEMBL24819174 | 0.75 | AAK1 (0.37) | NPC1RAB9AKDM4EHPGDBRD9 | |
| SCHEMBL30882153 | 0.75 | AAK1 (0.37) | NPC1RAB9AKDM4EHPGDBRD9 | |
| SCHEMBL30882154 | 0.75 | AAK1 (0.37) | NPC1RAB9AKDM4EHPGDBRD9 | |
| SCHEMBL25909101 | 0.75 | CYP17A1 (0.37) | NPC1RAB9AKDM4EHPGDBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0805812-B1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ(E)ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5792767-A | TREATMENT OF BENIGN PROSTATIC HYPERTROPY | ABBOTT LABORATORIES (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1996022991-A1 | BICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1- ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |