Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666976 | 0.87 | CES1 (0.61) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL7039215 | 0.76 | MAPT (0.57) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL1669227 | 0.75 | CES1 (0.57) | MAPTKMT2ACES1POLBCYP3A4 | |
| SCHEMBL27914495 | 0.74 | MAPT (0.52) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL1878464 | 0.74 | CES1 (0.52) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL1508202 | 0.73 | CES1 (0.56) | MAPTCES1TSHRCYP2C19POLB | |
| SCHEMBL15519395 | 0.73 | CES1 (0.56) | MAPTCES1TSHRCYP2C19POLB | |
| SCHEMBL461653 | 0.72 | CES1 (0.50) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL1168769 | 0.72 | CES1 (0.50) | MAPTKMT2ACES1TSHRCYP2C19 | |
| SCHEMBL8020656 | 0.72 | MAPT (0.52) | MAPTKMT2ACES1TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150565-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION bioscience AG (DE) | 2001-11-07 | — | — | EP | claimed |
| WO-2000045635-A1 | THIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2000-08-10 | — | — | WO | claimed |