Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.84 |
| ▸ | PPARD | Q03181 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7844584 | 1.00 | PTGS2 (0.84) | PTGS2PTGS1PPARD | |
| SCHEMBL7833376 | 0.91 | PTGS2 (0.75) | PTGS2PTGS1PPARD | |
| SCHEMBL7839927 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1PPARD | |
| SCHEMBL7834121 | 0.91 | PTGS2 (0.75) | PTGS2PTGS1PPARD | |
| SCHEMBL7842175 | 0.91 | PTGS2 (1.00) | PTGS2PTGS1PPARD | |
| SCHEMBL7842012 | 0.90 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL6442569 | 0.90 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL7845512 | 0.89 | PTGS2 (0.71) | PTGS2PTGS1PPARD | |
| SCHEMBL7843493 | 0.89 | PTGS2 (0.71) | PTGS2PTGS1PPARD | |
| SCHEMBL7842564 | 0.88 | PTGS2 (0.83) | PTGS2PTGS1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| EP-0772606-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003392-A1 | SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |