SCHEMBL7846953

SCHEMBL7846953

CC(=O)Nc1ccc2c(c1)OC1(CCN(CCc3ccccc3F)CC1)CC2=O

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ADRA1D P25100 10/20 0.59
ADRA1A P35348 9/20 0.59
ADRA1B P35368 8/20 0.59
HTR2A P28223 1/20 0.48
HDAC8 Q9BY41 2/20 0.44
HDAC6 Q9UBN7 2/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
OPRM1 P35372 1/20 0.44
KCNH2 Q12809 1/20 0.44
SIGMAR1 Q99720 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8569376 0.76 ADRA1D (0.75) ADRA1DADRA1AADRA1BHDAC8HDAC6
SCHEMBL1176447 0.76 HDAC3 (0.63) HTR2AHDAC8HDAC6HDAC3HDAC4
SCHEMBL1176445 0.76 HDAC3 (0.63) HTR2AHDAC8HDAC6HDAC3HDAC4
SCHEMBL11108781 0.75 KDM4E (0.52) HDAC8HDAC6HDAC3HDAC4HDAC1
SCHEMBL1175955 0.75 HDAC3 (0.67) ADRA1DADRA1AADRA1BHTR2AHDAC8
SCHEMBL1175960 0.75 HDAC3 (0.67) ADRA1DADRA1AADRA1BHTR2AHDAC8
SCHEMBL1175600 0.75 HDAC3 (0.79) HDAC8HDAC6HDAC3HDAC4HDAC1
SCHEMBL1175602 0.75 HDAC3 (0.79) HDAC8HDAC6HDAC3HDAC4HDAC1
SCHEMBL7848678 0.74 ADRA1D (1.00) ADRA1DADRA1AADRA1BKCNH2
SCHEMBL7852254 0.74 HDAC3 (0.54) ADRA1DADRA1AADRA1BHDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831824-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2001-05-02 EP claimed
EP-0831824-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-04-01 EP claimed
WO-1996039140-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-12-12 WO claimed
EP-0831824-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2001-05-02 EP disclosed
EP-0831824-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-04-01 EP disclosed
WO-1996039140-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-12-12 WO disclosed