Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 10/20 | 0.36 |
| ▸ | MMP3 | P08254 | 10/20 | 0.36 |
| ▸ | MMP7 | P09237 | 9/20 | 0.36 |
| ▸ | FCER2 | P06734 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847147 | 1.00 | MMP1 (0.43) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7849154 | 0.90 | MMP1 (0.45) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL7849158 | 0.90 | MMP1 (0.45) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL7849870 | 0.86 | HPGD (0.51) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7849871 | 0.86 | HPGD (0.51) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7955742 | 0.84 | MMP1 (0.49) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7955739 | 0.84 | MMP1 (0.49) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7846699 | 0.83 | MMP1 (0.43) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7846703 | 0.83 | MMP1 (0.43) | MMP1MMP13MMP8APPMMP2 | |
| SCHEMBL7837029 | 0.83 | MMP1 (0.34) | MMP1MMP13MMP8APPMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |