Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | WEE1 | P30291 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7855303 | 0.87 | FGFR4 (0.39) | ABL1FGFR1MAPK14EGFRLCK | |
| SCHEMBL3975918 | 0.85 | MAPK14 (0.53) | ABL1FGFR1MAPK14EGFRPDGFRB | |
| SCHEMBL7856079 | 0.81 | WEE1 (0.40) | FGFR1MAPK14EGFRSRCLCK | |
| SCHEMBL3970897 | 0.77 | MAPK14 (0.61) | ABL1FGFR1MAPK14EGFRPDGFRB | |
| SCHEMBL4208611 | 0.72 | FGFR4 (0.53) | ABL1FGFR1MAPK14EGFRLCK | |
| SCHEMBL3967358 | 0.67 | LCK (0.49) | ABL1FGFR1MAPK14EGFRLCK | |
| SCHEMBL23653059 | 0.65 | FGFR4 (0.64) | ABL1FGFR1MAPK14EGFRLCK | |
| SCHEMBL3970398 | 0.65 | LCK (0.51) | ABL1FGFR1MAPK14EGFRSRC | |
| SCHEMBL6695761 | 0.65 | ABL1 (0.40) | ABL1FGFR1MAPK14EGFRPDGFRB | |
| SCHEMBL16665345 | 0.64 | FGFR4 (0.53) | FGFR1FGFR4FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | claimed |