Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 7/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.34 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970398 | 0.85 | LCK (0.51) | WEE1EGFRFGFR1SRCLCK | |
| SCHEMBL7855303 | 0.81 | FGFR4 (0.39) | EGFRFGFR1LCKMAPK14FGFR4 | |
| SCHEMBL7847396 | 0.81 | ABL1 (0.39) | WEE1EGFRFGFR1SRCLCK | |
| SCHEMBL3968454 | 0.76 | LCK (0.61) | WEE1EGFRFGFR1SRCLCK | |
| SCHEMBL4208611 | 0.66 | FGFR4 (0.53) | WEE1EGFRFGFR1LCKMAPK14 | |
| SCHEMBL3968867 | 0.65 | LCK (0.51) | WEE1FGFR1SRCLCKMAPK14 | |
| SCHEMBL3972422 | 0.64 | LCK (0.65) | WEE1EGFRFGFR1SRCLCK | |
| SCHEMBL23653059 | 0.63 | FGFR4 (0.64) | WEE1EGFRFGFR1LCKMAPK14 | |
| SCHEMBL4479639 | 0.61 | TNK2 (0.52) | FGFR1SRCLCKFGFR4BRD4 | |
| SCHEMBL16665345 | 0.61 | FGFR4 (0.53) | FGFR1FGFR4FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080092-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999061444-A2 | BICYCLIC PYRIMIDINES AND BICYCLIC 3,4-DIHYDROPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |