Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.36 |
| ▸ | PPARA | Q07869 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL27508267 | 1.00 | MMP1 (0.42) | MMP1MMP2MMP3MMP8MMP13 | |
| Cyclohexylamine SCHEMBL7847566 | 1.00 | MMP1 (0.42) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL5098057 | 0.89 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL6943915 | 0.89 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7377622 | 0.89 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL6943911 | 0.89 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7372744 | 0.85 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7372741 | 0.85 | MMP1 (0.49) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7847561 | 0.83 | KMT2A (0.46) | MMP1MMP2MMP3MMP8MMP13 | |
| SCHEMBL7375195 | 0.78 | MMP1 (0.46) | MMP1MMP2MMP3MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1137640-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-04 | — | — | EP | disclosed |
| US-6281363-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS; AUTOIMMUNE DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |
| WO-2000035885-A1 | CYCLIC HYDRAZINE DERIVATIVES AS TNF-ALPHA INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-22 | — | — | WO | disclosed |