Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 12/20 | 0.63 |
| ▸ | PDE4A | P27815 | 10/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095763 | 1.00 | TNF (0.63) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL825636 | 0.90 | PDE4A (0.72) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL825963 | 0.87 | TNF (0.66) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6099935 | 0.85 | PDE4A (0.74) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7741527 | 0.85 | TNF (0.88) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6100831 | 0.83 | PDE4A (0.58) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7746332 | 0.81 | TNF (0.81) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23392622 | 0.78 | PDE4A (0.66) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1193475 | 0.77 | TP53 (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1194579 | 0.77 | PDE4B (0.74) | TNFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035848-A4 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORP (US) | 2001-05-23 | — | — | EP | disclosed |
| EP-1035848-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNF-ALPHA LEVELS | CELGENE CORPORATION (US) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999006041-A1 | SUBSTITUTED ALKANOHYDROXAMIC ACIDS AND METHOD OF REDUCING TNFα LEVELS | CELGENE CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |