Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2996285 | 0.90 | EGFR (0.71) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL7849226 | 0.86 | EGFR (0.56) | EGFRERBB2KDRSRCERBB4 | |
| SCHEMBL1417787 | 0.85 | EGFR (0.86) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL2989673 | 0.82 | EGFR (0.72) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL1418055 | 0.80 | EGFR (0.77) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL1419134 | 0.80 | EGFR (0.83) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL14356869 | 0.79 | EGFR (1.00) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL1418027 | 0.79 | EGFR (0.82) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL1418806 | 0.79 | EGFR (0.82) | EGFRERBB2KDRFYNSRC | |
| SCHEMBL1418015 | 0.79 | EGFR (0.64) | EGFRERBB2KDRFYNSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |