Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.50 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333875 | 0.77 | NR1H4 (0.46) | RXRARXRBRXRGPSEN1PSEN2 | |
| SCHEMBL693269 | 0.77 | SRD5A2 (0.90) | SRD5A2CYP2C8RXRARXRBRXRG | |
| SCHEMBL5023264 | 0.76 | TNIK (0.46) | MAPK1MAP2K4MAPK6MAPKAPK3KMT2A | |
| SCHEMBL69008 | 0.74 | MEN1 (0.50) | MAPK1MAP2K4MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL28936490 | 0.74 | SRD5A2 (0.57) | SRD5A2CYP2C8MEN1LMNAKMT2A | |
| SCHEMBL5022735 | 0.73 | TNIK (0.43) | KMT2A | |
| SCHEMBL26477869 | 0.72 | RAF1 (0.55) | MAPK1MAP2K4MAPK6MAPKAPK3MAPKAPK5 | |
| SCHEMBL28775522 | 0.72 | HTR2C (0.45) | — | |
| SCHEMBL505133 | 0.72 | SRD5A2 (0.77) | SRD5A2MAPK1MAP2K4MAPK6MAPKAPK3 | |
| SCHEMBL30737531 | 0.71 | HDAC1 (0.54) | PPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150958-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | Bayer Aktiengesellschaft (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046208-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-10 | — | — | WO | disclosed |