Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | AANAT | Q16613 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853054 | 0.93 | HPGD (0.62) | HPGDHTTRECQLSLC6A4MAPT | |
| SCHEMBL7675954 | 0.89 | HPGD (0.69) | HPGDHTTRECQLMAPTALDH1A1 | |
| SCHEMBL8240955 | 0.82 | SLC6A4 (0.69) | HTTSLC6A4MAPTALDH1A1BCHE | |
| SCHEMBL22610217 | 0.81 | BCHE (0.69) | SLC6A4BCHEACHEMEN1KMT2A | |
| SCHEMBL3602531 | 0.81 | HPGD (0.61) | HPGDHTTRECQLMAPTALDH1A1 | |
| SCHEMBL1854450 | 0.80 | NPY5R (0.61) | HPGDHTTRECQLMAPTALDH1A1 | |
| SCHEMBL10119656 | 0.79 | SLC6A4 (0.69) | HPGDHTTRECQLSLC6A4MAPT | |
| SCHEMBL7675493 | 0.79 | SLC6A4 (0.58) | RECQLSLC6A4MAPTALDH1A1BCHE | |
| SCHEMBL7845295 | 0.79 | HPGD (1.00) | HPGDHTTRECQLMAPTALDH1A1 | |
| SCHEMBL7677886 | 0.79 | MEN1 (0.84) | MAPTALDH1A1GAAGFERMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140914-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037462-A1 | NON-PEPTIDE NK1 RECEPTORS ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |