Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | FLT1 | P17948 | 4/20 | 0.42 |
| ▸ | FLT4 | P35916 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | TEK | Q02763 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6366685 | 0.89 | KDR (0.49) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL7848576 | 0.87 | PDGFRB (0.48) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL7847211 | 0.83 | KDR (0.45) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL4380414 | 0.82 | KDR (0.49) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL7845204 | 0.82 | KDR (0.45) | KDRRAF1EGFRMETTEK | |
| SCHEMBL4377455 | 0.82 | FLT4 (0.63) | KDREGFRFLT1FLT4FGFR1 | |
| SCHEMBL4377781 | 0.81 | KDM1A (0.47) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL7848071 | 0.81 | KDM1A (0.47) | KDM1AKDRRAF1EGFRFLT1 | |
| SCHEMBL4375820 | 0.81 | EGFR (0.53) | KDRRAF1EGFRFLT1FLT4 | |
| SCHEMBL7837010 | 0.80 | KDM1A (0.44) | KDM1AKDRRAF1EGFRFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |