Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 11/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 6/20 | 0.42 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7837010 | 0.90 | KDM1A (0.44) | KDM1ARAF1KDREGFRPDGFRA | |
| SCHEMBL6366685 | 0.85 | KDR (0.49) | KDM1ARAF1KDREGFRPDGFRA | |
| SCHEMBL7848576 | 0.85 | PDGFRB (0.48) | KDM1ARAF1KDREGFRPDGFRA | |
| SCHEMBL7847211 | 0.84 | KDR (0.45) | KDM1ARAF1KDREGFRPDGFRA | |
| SCHEMBL7847869 | 0.81 | KDM1A (0.43) | KDM1ARAF1KDREGFRPDGFRA | |
| SCHEMBL7846902 | 0.80 | KDR (0.45) | KDM1ARAF1PDE3BPDE3APDE10A | |
| SCHEMBL4374206 | 0.79 | EGFR (0.59) | RAF1KDREGFRKIT | |
| SCHEMBL4373993 | 0.79 | FLT4 (0.63) | KDREGFRPDGFRAFLT4FLT1 | |
| SCHEMBL4377415 | 0.78 | KDM1A (0.52) | KDM1AKDREGFRPDGFRAFLT4 | |
| SCHEMBL41746 | 0.77 | KDR (0.67) | KDREGFRPDGFRAFLT4FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |