Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 13/20 | 0.51 |
| ▸ | KDR | P35968 | 11/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.51 |
| ▸ | MERTK | Q12866 | 2/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | FLT1 | P17948 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | FLT4 | P35916 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7854761 | 0.99 | EPHA2 (0.51) | EPHA2KDREPHB4AXLMERTK | |
| SCHEMBL7848480 | 0.85 | RET (0.70) | EPHA2KDREPHB4AXLMERTK | |
| SCHEMBL7847211 | 0.83 | KDR (0.45) | KDREPHB4AXLMERTKTYRO3 | |
| SCHEMBL4378175 | 0.81 | KDR (0.59) | KDREGFRFLT1FGFR1RET | |
| SCHEMBL6099428 | 0.81 | EGFR (0.65) | KDREGFRERBB2RET | |
| SCHEMBL4373829 | 0.81 | EGFR (0.67) | EPHA2KDREPHB4AXLMERTK | |
| Hydrochloric Acid SCHEMBL6362646 | 0.80 | EGFR (0.50) | EPHA2KDREPHB4EGFRRET | |
| Hydrochloric Acid SCHEMBL4373692 | 0.80 | EGFR (0.66) | EPHA2KDREPHB4AXLEGFR | |
| SCHEMBL4380534 | 0.80 | EGFR (0.69) | EGFR | |
| SCHEMBL4380962 | 0.80 | EGFR (0.64) | KDREGFRFLT4ERBB2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |