Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.69 |
| ▸ | PTPRC | P08575 | 2/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.69 |
| ▸ | PTPRB | P23467 | 2/20 | 0.69 |
| ▸ | PTPRE | P23469 | 2/20 | 0.69 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.69 |
| ▸ | PTPRA | P18433 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11494815 | 0.83 | PTPN1 (0.67) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL5409391 | 0.82 | TDP1 (0.55) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7989039 | 0.81 | PTPN1 (1.00) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7988908 | 0.81 | KDM4E (0.70) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7850074 | 0.81 | PTPN1 (0.65) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL7836703 | 0.81 | PTPN1 (0.65) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL31451940 | 0.81 | KDM4E (0.69) | KMT2AALDH1A1MAPTMEN1TDP1 | |
| SCHEMBL28253565 | 0.81 | KMT2A (0.57) | PTPN1PTPRCPTPN2PTPRBPTPRE | |
| SCHEMBL8533041 | 0.81 | KDM4E (0.69) | KMT2AALDH1A1MAPTMEN1TDP1 | |
| SCHEMBL20466337 | 0.80 | CA12 (0.57) | PTPN1PTPRCPTPN2PTPRBPTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | claimed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | claimed |
| US-6225329-B1 | USEFUL IN THE TREATMENT OF TYPE I DIABETES, TYPE II DIABETES, IMPAIRED GLUCOSE TOLERANCE, INSULIN AUTOIMMUNITY DISEASES WITH DYSFUNCTIONS OF THE COAGULATION SYSTEM, ALLERGIC DISEASES | NOVO NORDISK A/S (DK) | 2001-05-01 | — | — | US | disclosed |
| EP-1080068-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | Novo Nordisk A/S (DK) | 2001-03-07 | — | — | EP | disclosed |
| EP-1062199-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 2000-12-27 | — | — | EP | disclosed |
| WO-1999046237-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |
| WO-1999046236-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPASES) | NOVO NORDISK A/S (DK) | 1999-09-16 | — | — | WO | disclosed |