SCHEMBL5409391

SCHEMBL5409391

C=C(C)C(=O)Nc1ccc(O)cc1C(=O)O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.55
KMT2A Q03164 5/20 0.55
ALDH1A1 P00352 5/20 0.55
MAPT P10636 4/20 0.55
MEN1 O00255 4/20 0.55
HTT P42858 1/20 0.55
LMNA P02545 1/20 0.52
RAB9A P51151 1/20 0.52
HSD17B10 Q99714 4/20 0.49
KDM4E B2RXH2 3/20 0.49
PTPN1 P18031 2/20 0.49
PTPRC P08575 1/20 0.49
PTPN2 P17706 1/20 0.49
PTPRA P18433 1/20 0.49
PTPRB P23467 1/20 0.49
PTPRE P23469 1/20 0.49
PTPN6 P29350 1/20 0.49
ABL1 P00519 2/20 0.48
RIN1 Q13671 2/20 0.48
TSHR P16473 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9621680 0.89 ALDH1A1 (0.46) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL29140026 0.84 MAPT (0.57) KMT2AALDH1A1MAPTMEN1LMNA
SCHEMBL3044265 0.84 KDM4E (0.71) ALDH1A1HSD17B10KDM4ECA12CA1
SCHEMBL13921949 0.84 CA12 (0.56) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL14339913 0.84 POLB (0.56) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL22200960 0.83 POLB (0.49) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL7848426 0.82 PTPN1 (0.69) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL31451940 0.82 KDM4E (0.69) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL8533041 0.82 KDM4E (0.69) TDP1KMT2AALDH1A1MAPTMEN1
SCHEMBL3628065 0.81 PTPN1 (0.45) TDP1KMT2AALDH1A1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7259210-B2 Bone cement and a system for mixing and delivery thereof THE UAB RESEARCH FOUNDATION (US) 2007-08-21 US disclosed
EP-1367960-B1 BONE CEMENT UAB RESEARCH FOUNDATION (US) 2005-11-02 EP disclosed
US-20040132859-A1 Bone cement and a system for mixing and delivery thereof PUCKETT JR AARON D (US) 2004-07-08 US disclosed
EP-1367960-A4 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF UAB RESEARCH FOUNDATION (US) 2004-06-09 EP disclosed
EP-1367960-A2 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF UAB Research Foundation (US) 2003-12-10 EP disclosed
WO-2002058592-A9 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF UAB RESEARCH FOUNDATION (US) 2003-11-27 WO disclosed
WO-2002058592-A2 BONE CEMENT AND A SYSTEM FOR MIXING AND DELIVERY THEREOF UAB RESEARCH FOUNDATION (US) 2002-08-01 WO disclosed
EP-0323521-B1 CURABLE COMPOSITION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1992-03-18 EP disclosed
US-4920188-A (Meth)acrylate monomer; dental bonding agent MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1990-04-24 US disclosed
EP-0323521-A1 CURABLE COMPOSITION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-07-12 EP disclosed