Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 12/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 5/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846902 | 0.76 | KDR (0.45) | RAF1KDRAURKAMETTEK | |
| SCHEMBL7847135 | 0.75 | KDR (0.45) | KDRAURKAMETTEKAURKB | |
| SCHEMBL6366468 | 0.74 | KDR (0.43) | KDRAURKAMETTEKAURKB | |
| SCHEMBL7848154 | 0.74 | KDR (0.43) | RAF1KDRAURKAMETTEK | |
| SCHEMBL7847654 | 0.74 | KDR (0.44) | RAF1KDRAURKAMETTEK | |
| SCHEMBL7845204 | 0.73 | KDR (0.45) | RAF1KDRAURKAMETTEK | |
| SCHEMBL7885975 | 0.72 | KDR (0.41) | KDRAURKAMETTEKAURKB | |
| SCHEMBL7854726 | 0.69 | KDR (0.42) | KDRAURKAMETTEKAURKB | |
| SCHEMBL5682902 | 0.69 | KDR (0.46) | KDRMETTEKAURKBRET | |
| SCHEMBL6774386 | 0.68 | KDM4E (0.46) | KDRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |