Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KIF5B | P33176 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7847135 | 0.83 | KDR (0.45) | KDREGFRLCKRETKIF5B | |
| SCHEMBL6366468 | 0.83 | KDR (0.43) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7845204 | 0.80 | KDR (0.45) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7848071 | 0.80 | KDM1A (0.47) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7885975 | 0.77 | KDR (0.41) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7850002 | 0.76 | KDR (0.43) | KDREGFRLCKRETKIF5B | |
| SCHEMBL4374206 | 0.76 | EGFR (0.59) | KDREGFRKITRAF1 | |
| SCHEMBL4371957 | 0.76 | KDR (0.58) | KDREGFRLCKPDGFRAKIT | |
| SCHEMBL7837879 | 0.76 | KDR (0.47) | KDREGFRLCKRETKIF5B | |
| SCHEMBL7848549 | 0.76 | RAF1 (0.42) | KDRRETKIF5BAURKAMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154774-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AstraZeneca AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000047212-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2000-08-17 | — | — | WO | disclosed |