Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2980235 | 0.90 | SIRT6 (0.51) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL7822905 | 0.90 | MAPT (0.49) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL7853049 | 0.87 | HDAC3 (0.49) | ALDH1A1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL2978967 | 0.83 | MAPT (0.58) | ALDH1A1MAPTLMNANPC1KMT2A | |
| SCHEMBL7822850 | 0.83 | MAPT (0.48) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL7825920 | 0.83 | MAPT (0.41) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL2969766 | 0.82 | HDAC3 (0.51) | ALDH1A1MAPTNPC1KMT2AMEN1 | |
| SCHEMBL7825494 | 0.82 | KMT2A (0.49) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL6401762 | 0.81 | SIRT6 (0.54) | ALDH1A1MAPTPOLBLMNANPC1 | |
| SCHEMBL2979467 | 0.81 | MAPT (0.50) | ALDH1A1MAPTPOLBLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163237-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000055153-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-09-21 | — | — | WO | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |