Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 16/20 | 0.61 |
| ▸ | NPFFR2 | Q9Y5X5 | 16/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831492 | 0.83 | NPFFR1 (0.54) | NPFFR1NPFFR2OPRK1KDM4EALDH1A1 | |
| SCHEMBL7834387 | 0.83 | ALDH1A1 (0.55) | NPFFR1NPFFR2OPRK1KDM4EALDH1A1 | |
| SCHEMBL7853470 | 0.83 | NPFFR1 (0.49) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL7707050 | 0.83 | ALDH1A1 (0.61) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL7853472 | 0.81 | KDM4E (0.50) | NPFFR1NPFFR2OPRK1OPRM1KDM4E | |
| SCHEMBL7830278 | 0.80 | ALDH1A1 (0.63) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11447661 | 0.79 | KDM4E (0.50) | NPFFR1NPFFR2OPRK1OPRM1KDM4E | |
| SCHEMBL7831915 | 0.76 | ALDH1A1 (0.54) | OPRM1OPRD1KDM4EALDH1A1MAPT | |
| SCHEMBL18719636 | 0.75 | KDM4E (0.56) | KDM4EALDH1A1MAPTRAB9ADCUN1D1 | |
| SCHEMBL7705959 | 0.73 | SMN1; SMN2 (0.59) | NPFFR1NPFFR2OPRM1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6248756-B1 | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. | 2001-06-19 | — | — | US | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| US-5891889-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |