Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | CCR4 | P51679 | 10/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362617 | 0.91 | ABCB11 (0.77) | EDNRAABCB11CCR4 | |
| SCHEMBL7365241 | 0.90 | ABCB11 (0.75) | EDNRAABCB11CCR4 | |
| SCHEMBL30296218 | 0.89 | ABCB11 (0.75) | EDNRAABCB11CCR4 | |
| SCHEMBL7359279 | 0.89 | ABCB11 (0.75) | EDNRAABCB11CCR4 | |
| SCHEMBL7362063 | 0.89 | ABCB11 (0.74) | EDNRAABCB11CCR4 | |
| SCHEMBL7364693 | 0.89 | ABCB11 (0.74) | EDNRAABCB11CCR4 | |
| SCHEMBL8038435 | 0.89 | ABCB11 (0.74) | EDNRAABCB11CCR4 | |
| SCHEMBL7358677 | 0.88 | ABCB11 (0.73) | EDNRAABCB11CCR4 | |
| SCHEMBL7358576 | 0.87 | ABCB11 (0.78) | EDNRAABCB11CCR4 | |
| SCHEMBL7364200 | 0.87 | ABCB11 (0.72) | EDNRAABCB11CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832082-B1 | N-HETEROARYL-PYRIDINESULFONAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-11-21 | — | — | EP | disclosed |
| US-6258817-B1 | PRODRUGS, HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | ZENECA LTD. (GB) | 2001-07-10 | — | — | US | disclosed |