Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KIF20A | O95235 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LDLR | P01130 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842158 | 0.81 | DYRK1A (0.49) | KIF20ACHEK1DYRK1ACLK1CLK2 | |
| SCHEMBL714052 | 0.68 | MEN1 (0.39) | NPC1RAB9AKMT2A | |
| SCHEMBL210495 | 0.67 | — | — | |
| SCHEMBL5563994 | 0.66 | — | — | |
| SCHEMBL709806 | 0.66 | MEN1 (0.34) | NPC1RAB9AKMT2A | |
| SCHEMBL7833438 | 0.65 | MEN1 (0.33) | ALDH1A1KMT2A | |
| SCHEMBL7851457 | 0.64 | MAPT (0.73) | MAPTKIF20ASMN1; SMN2RECQLHIF1A | |
| SCHEMBL7851385 | 0.64 | MAPT (0.73) | MAPTKIF20ASMN1; SMN2RECQLHIF1A | |
| SCHEMBL8977344 | 0.64 | CYP2A6 (0.48) | MAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4711859 | 0.63 | ALDH1A1 (0.38) | SMN1; SMN2HIF1AKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835244-B1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PROD (US) | 2001-12-05 | — | — | EP | claimed |
| EP-0835244-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-15 | — | — | EP | claimed |
| US-5710164-A | Diheterocyclic styryl nitriles | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-20 | — | — | US | claimed |
| WO-1996039387-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | claimed |
| EP-0835244-B1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PROD (US) | 2001-12-05 | — | — | EP | disclosed |
| EP-0835244-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5710164-A | Diheterocyclic styryl nitriles | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-20 | — | — | US | disclosed |
| WO-1996039387-A1 | DIHETEROCYCLIC ACRYLONITRILES AS SMOOTH MUSCLE CELL PROLIFERATION INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-12 | — | — | WO | disclosed |