Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5897069 | 0.92 | MAPK14 (0.60) | MAPK14BRAF | |
| SCHEMBL7850678 | 0.83 | MAPT (0.60) | MAPK14 | |
| SCHEMBL7851337 | 0.82 | MAPK14 (0.52) | MAPK14BRAF | |
| SCHEMBL5897180 | 0.81 | MAPK14 (0.73) | MAPK14BRAF | |
| SCHEMBL7804539 | 0.76 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL26033639 | 0.74 | MAPK14 (0.52) | MAPK14BRAFLCK | |
| SCHEMBL5897317 | 0.74 | MAPK14 (0.66) | MAPK14BRAF | |
| SCHEMBL16620903 | 0.74 | PIR (0.58) | MAPK14BRAF | |
| SCHEMBL7848504 | 0.73 | CSF1R (0.64) | MAPK14BRAF | |
| SCHEMBL5897677 | 0.73 | MAPK14 (0.63) | MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | claimed |
| EP-1102750-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007991-A1 | AMIDE DERIVATIVES USEFUL AS INHIBITORS OF THE PRODUCTION OF CYTOKINES | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |