SCHEMBL7849568

SCHEMBL7849568

O=C(Nc1ccc2c(c1)C(=O)CC1(CCNCC1)O2)OCc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
NPC1 O15118 1/20 0.53
TP53 P04637 1/20 0.53
MAPT P10636 1/20 0.53
TSHR P16473 1/20 0.53
RAB9A P51151 1/20 0.53
ATM Q13315 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
HDAC3 O15379 9/20 0.49
HDAC4 P56524 9/20 0.49
HDAC1 Q13547 9/20 0.49
HDAC7 Q8WUI4 9/20 0.49
HDAC2 Q92769 9/20 0.49
HDAC10 Q969S8 9/20 0.49
HDAC11 Q96DB2 9/20 0.49
HDAC8 Q9BY41 9/20 0.49
HDAC6 Q9UBN7 9/20 0.49
HDAC9 Q9UKV0 9/20 0.49
HDAC5 Q9UQL6 9/20 0.49
KDM4E B2RXH2 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL744065 0.84 HDAC3 (0.56) ALDH1A1ATMHDAC3HDAC4HDAC1
SCHEMBL13339676 0.83 HDAC3 (0.52) ALDH1A1NPC1MAPTRAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL3493153 0.82 HDAC3 (0.52) ALDH1A1NPC1MAPTRAB9ASMN1; SMN2
Hydrochloric Acid SCHEMBL4278683 0.81 HDAC3 (0.58) ATMHDAC3HDAC4HDAC1HDAC7
SCHEMBL1811484 0.79 HDAC3 (0.58) ATMHDAC3HDAC4HDAC1HDAC7
SCHEMBL11246168 0.79 TP53 (0.60) ALDH1A1NPC1TP53MAPTTSHR
SCHEMBL13339743 0.79 ALDH1A1 (0.56) ALDH1A1NPC1RAB9ASMN1; SMN2HDAC3
Hydrochloric Acid SCHEMBL3492500 0.78 ALDH1A1 (0.56) ALDH1A1NPC1RAB9ASMN1; SMN2HDAC3
SCHEMBL15178391 0.76 HDAC3 (0.56) ALDH1A1ATMHDAC3HDAC4HDAC1
SCHEMBL3493476 0.74 HDAC3 (0.56) ALDH1A1ATMHDAC3HDAC4HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831824-A4 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2001-05-02 EP disclosed
EP-0831824-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-04-01 EP disclosed
WO-1996039140-A1 ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1996-12-12 WO disclosed