Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.41 |
| ▸ | DUS2 | Q9NX74 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12525787 | 0.80 | EGFR (0.57) | EGFRERBB2ERBB4ABL1 | |
| SCHEMBL29737288 | 0.79 | EGFR (0.59) | EGFRERBB2ERBB4SRCERBB3 | |
| SCHEMBL27595565 | 0.78 | RAF1 (0.46) | EGFRERBB2ERBB4ERBB3DUS2 | |
| SCHEMBL3544316 | 0.78 | EGFR (0.55) | EGFRERBB2ERBB4SRCERBB3 | |
| SCHEMBL16986930 | 0.77 | EGFR (0.56) | EGFRERBB2ERBB4SRCERBB3 | |
| SCHEMBL1417948 | 0.77 | EGFR (0.67) | EGFRERBB2ERBB4HDAC3HDAC4 | |
| SCHEMBL6789229 | 0.76 | EGFR (0.46) | EGFRERBB2ERBB4PDGFRB | |
| SCHEMBL27704368 | 0.76 | EGFR (0.63) | EGFRERBB2ERBB4SRC | |
| SCHEMBL7852173 | 0.76 | EGFR (0.59) | EGFRERBB2ERBB4SRC | |
| SCHEMBL5374589 | 0.76 | EGFR (0.49) | EGFRERBB2ERBB4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1341104-A | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-03-20 | — | — | CN | disclosed |
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |